Dose of warfarin

Warfarin Uses, Dosage, Side Effects - Drugs

Take warfarin at the same time every day, with or without food. Never take a double dose. Warfarin can make it easier for you to bleed. Seek emergency help if you have any bleeding that will not stop. You will need frequent INR or prothrombin time tests (to measure your blood-clotting time and determine your warfarin dose) Initial dose: 2-5 mg PO/IV qDay for 2 days, OR 10 mg PO for 2 days in healthy individuals. Initiate warfarin on day 1 or 2 of LMWH or unfractionated heparin therapy and overlap until desired INR,.. If the patient's CYP2C9 and VKORC1 genotypes are not known, the initial dose of Warfarin sodium is usually 2 to 5 mg once daily. Determine each patient's dosing needs by close monitoring of the INR response and consideration of the indication being treated. Typical maintenance doses are 2 to 10 mg once daily Your dose of warfarin sodium is based on your prothrombin time (PT)/international normalized ratio (INR) blood test. The typical starting dose is 5 mg to 10 mg once per day

Adjust the warfarin dose to maintain a target INR of 2.5 (INR range, 2.0-3.0) for all treatment durations. The duration of treatment is based on the indication as follows: For patients with a DVT or PE secondary to a transient (reversible) risk factor, treatment with warfarin for 3 months is recommended The following general recommendations for warfarin use are made. Initiate therapy with the estimated daily maintenance dose (2-5 mg.). Elderly or debilitated patients often require low daily doses of warfarin (2-4 mg.). Patients are confused by alternating daily doses (e.g. 7.5 and 5.0 mg) Varies: I love dr. Klein's answer: the dose that works. he is absolutely right. Certain south-east Asian populations have the genetics he mentioned that makes them require higher doses of Coumadin (warfarin) than others the same weight. Generally, smaller people need less than larger, too, but not always. Diet has a lot to do with dosage need

Warfarin prophylaxis can be administered by two methods (Box 5-4). The first protocol is to give warfarin, 10 mg, the night before surgery. This dose is followed by 5 mg the evening of surgery. The daily dose is determined by the prothrombin time (PT) converted to the international normalized ratio (INR) The two widely used dosing options on the initiation of warfarin therapy are 5 mg and 10 mg per day. A small study 1 randomized 49 inpatients to receive initial doses of 5 mg or 10 mg, with..

Coumadin, Jantoven (warfarin) dosing, indications

  1. ed to be age-dependent
  2. Warfarin should usually be started at a dose of 5 mg per day.A 10-mg dose more frequently results in a supratherapeutic international normalized ratio (INR). Amiodarone, fluconazole, metronidazole, trimethoprim- sulfamethoxazole, and many other drugs inhibit the metabolism of warfarin
  3. Example: Your patient has been taking warfarin 5mg daily for more than 2 weeks and INR is 1.8. Adding 5mg to the week (for instance, 5mg Monday-Friday with 7.5mg Saturday-Sunday) should increase the INR into the mid-2s
  4. The usual warfarin dose is 10mg a day for the first 2 days, then between 3mg and 9mg a day after that. Warfarin tablets come in 4 different strengths. The tablets and the boxes they come in are different colours to make it easier for you to take the right dose
  5. Results: The warfarin dose was inversely related to age and was strongly associated with gender. The median weekly dose ranged from 45 mg (6.4 mg/d) for men who were < 50 years of age to 22 mg (3.1 mg/d) for women > 80 years of age

Warfarin - FDA prescribing information, side effects and use

Warfarin 1 or 2 mg each day is generally an acceptable starting dose. A low starting dose is often more suitable for frail or elderly people and people at high risk of bleeding. The average daily maintenance dose is usually around 5 mg daily, however there is wide variation and the daily dose may be between 1-15 mg for some people The inclusion of the CYP4F2 in warfarin dosing models that included CYP2C9, VKORC1 and clinical factors improved the accuracy of dose prediction. CYP2C9 Individuals who inherit 1 or 2 copies of CYP2C9*2 or *3 are at greater risk of bleeding during warfarin therapy, compared to patients homozygous for CYP2C9*1 Warfarin is the most widely used oral anticoagulant agent worldwide; more than 30 million prescriptions were written for this drug in the United States in 2004. 1 The appropriate dose of warfarin. Warfarin. If you're taking warfarinand you miss one of your doses, you should skip the dose you missed and wait to take your next scheduled dose as normal. Don't take a double dose to make up for the one you missed. If you accidentally take a dose that was much higher than recommended, contact your anticoagulant clinic or GP for advice For oral dosage form (tablets): For prevention or treatment of blood clots: Adult—At first, 2 to 5 milligrams (mg) as a single dose once per day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 10 mg per day. Children—Use and dose must be determined by your doctor. Missed Dose

Warfarin is taken once a day, usually in the evening. It's important to take your dose at the same time each day, before, during or after a meal. The aim of warfarin therapy is to decrease the blood's tendency to clot, but not stop it clotting completely Examples of warfarin dose algorithms are shown in Table 11.9. The performance of these algorithms varies between populations, partly due to different frequencies of the included variables. 95 For example, the aggregated allele frequencies of ∗2 and ∗3 range from 4% in Asians and Africans to 20% in whites. Warfarin can cause major or fatal bleeding. Regular monitoring of INR should be performed on all treated patients. Drugs, dietary changes, and other factors affect INR levels achieved with warfarin sodium therapy. Instruct patients about prevention measures to minimize risk of bleeding and to report signs and symptoms of bleeding Warfarin, sold under the brand name Coumadin among others, is a medication that is used as an anticoagulant (blood thinner). It is commonly used to treat blood clots such as deep vein thrombosis and pulmonary embolism, and to prevent stroke in people who have atrial fibrillation, valvular heart disease or artificial heart valves. Less commonly it is used following ST-segment elevation.

Warfarin: Side Effects, Dosage, Uses, and Mor

The 10mg initiation nomogram should only be used in relatively young and healthy patients who are likely to be insensitive to warfarin, or in patients taking concurrent medications known to induce warfarin metabolism. Please note that loading doses of warfarin are NOT RECOMMENDED The warfarin dose should be titrated against measured INR when used in treating established thromboembolism. Accidental overdoses are resolved with infusion of fresh frozen plasma to correct the coagulation disorder or administration of vitamin K to rapidly correct INR, however, this method does interfere with subsequent treatment efforts if. The warfarin dose should be titrated against measured INR when used in treating established thromboembolism. In case an accidental overdose occurs, vitamin K is administered to rapidly correct INR or infusion of fresh frozen plasma is used to further correct the coagulation disorder In selected patients (e.g., very large individuals or those on medications known to antagonize warfarin), a Day 1 warfarin dose of 7.5 mg may be appropriate. The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment You will take warfarin every day. The dose usually ranges from 1 mg to 10 mg. Your healthcare provider will prescribe a specific dosage strength, however, keep in mind that this dosage may change based on the results of each laboratory test. Other instructions for taking warfarin include: Take your dose of warfarin as instructed once a day

Warfarin Maintenance Dose Consult Tool. Warfarin Maintenance Adjustment Calculator: Background: This program may be useful in an outpatient or inpatient setting to help make adjustments to therapy for patients currently receiving warfarin who are no longer in the therapeutic range at admission or during a clinic visit Warfarin Reversal • Kcentra® Dosing -Administer with Vitamin K concurrently * Dose based on actual potency as stated on the carton Pre-treatment INR 2 - <4 4 - 6 >6 Dose* of Kcentra (Units of Factor IX) / kg body weight 25 35 50 Maximum dose (units of Factor IX) Not to exceed 2500 Not to exceed 3500 Not to exceed 500 about any dose changes to make during your office visit (before you have taken your dose for the day). Other tips for taking your warfarin safely • Keep a record on your calendar of any day(s) you forgot to take a dose, and tell your anticoagulation clinic pharmacist at your next office visit. • Pill organizers are a great way to keep track. Hold warfarin (Coumadin) and administer vitamin K (grade 2C), increase frequency of monitoring, repeat vitamin K as necessary, and resume warfarin at an appropriate dosage when INR is within the. Drug Interaction Classification Systems: Significance Rating (A) Criteria Management Rating (B) Criteria: 0: Not listed 0: Not listed: 1: Severity - Major: The effects are potentially life-threatening or capable of causing permanent damage. Documentation: interaction is suspected, probable or established

Coumadin Dosage Guide - Drugs

Warfarin Therapy Management - Province of British Columbia

The amount of warfarin that you need to take will depend upon the result of these blood tests, and this is why your dose may change from time to time. The aim is to get the dose of warfarin just right so your blood does not clot as easily as normal, but not so much as to cause bleeding problems Dosage of oral anticoagulants should be guided by using Computerised Decision Support Software (CDSS) or by approved clinical guidelines (example included - Appendix 1). 5.3. Dosing should not be increased by more than 5-20% weekly dose. 5.4. There is no maximum dose of warfarin but most patients require 2mg to 10mg per day

Warfarin Coumadin INR Protime Doses Dosing Algorithm

Warfarin INR Testing

whats the maximum dosage of coumadin (warfarin)? Answers

  1. Take warfarin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Call your doctor immediately if you take more than your prescribed dose of warfarin. Your doctor will probably start you on a low dose of warfarin and gradually increase or decrease your dose based on the results of your blood.
  2. Warfarin 1. بسم الله الرحمن الرحيم<br /> 2. WarfarinCoumadin® the most common anticoagulant drug<br />By <br />Taher Haddad<br />King Faisal University<br />College of Clinical Pharmacy<br />
  3. Objective: The optimal anticoagulant therapy during pregnancy in women with mechanical heart valves remains controversial. This study highlights a case of high-dose warfarin ingestion throughout pregnancy and performed a systematic review to assess rates of teratogenicity with high versus low warfarin dosing (≤5 mg daily)
  4. Warfarin is an anticoagulant (blood thinner). Warfarin reduces the formation of blood clots. Warfarin is used to treat or prevent blood clots in veins or arteries, which can reduce the risk of.

Warfarin - an overview ScienceDirect Topic

  1. Warnings. Warfarin sodium can cause major or fatal bleeding; bleeding is more likely to occur during the starting period and with a higher dose (resulting in a higher INR); Risk factors for bleeding include high intensity of anticoagulation (INR greater than 4), age 65 years or older, highly variable INRs, history of gastrointestinal bleeding, hypertension, cerebrovascular disease, serious.
  2. Anticoagulation with warfarin can be initiated in previously untreated patients with an approximated average maintenance dosage of 5 mg daily or with a loading dose of 10 or 15 mg once daily 1.The objective of the more intensive initial dosing is to achieve therapeutic levels of the international normalized ratio (INR) faster, which for some patients can take 10-14 days 2
  3. The subsequent mean decrease in warfarin dose was 24.6% (95% confidence interval [CI], 23.5, 25.6). The frequency of INR monitoring within 1 and 2 weeks after initiation of amiodarone was 67% and 90%. Conclusions Although warfarin doses in most patients were within the therapeutic range, more than one in three patients initiating co-treatment.

In Australia, field trials evaluating baits containing 0.09% warfarin resulted in wild pig population reduction >95%. The objective of this study was to conduct an EPA-approved field trial to evaluate the use of bait containing low-dose warfarin (0.01% and 0.005%) in reducing wild pig numbers in Texas The effects of warfarin can last quite a long time in the body but it takes about two to four days to see these effects. This means that a change in dose will not be reflected in the blood test until this time. All this needs to be taken into account when deciding on the dose of warfarin Autumn Rivers Date: January 07, 2021 Signs of a warfarin overdose may include unexplained bruises.. Since warfarin is meant to prevent blood clots, an overdose often results in excessive bleeding in various parts of the body, meaning that it can be quite dangerous to take too much of this drug.One of the most common results of a warfarin overdose is bleeding under the skin, which usually. Suggest as a translation of dose of warfarin Copy; DeepL Translator Linguee. EN. Open menu. Translator. Translate texts with the world's best machine translation technology, developed by the creators of Linguee. Linguee. Look up words and phrases in comprehensive, reliable bilingual dictionaries and search through billions of online translations Apixaban Warfarin When going from apixaban to warfarin, consider the use of parenteral anticoagulation as a bridge (eg, start heparin infusion or therapeutic enoxaparin AND warfarin 12 hours after last dose of apixaban and discontinue parenteral anticoagulant when INR is therapeutic)

Warfarin Sodium 3mg Tablets

Evidence-Based Initiation of Warfarin (Coumadin) - Point

  1. ister 1 to 2.5 mg phytonadione orally. One milligram of phytonadione may be ad
  2. Introduction. Warfarin is the most common oral anticoagulation drug, prescribed for the prevention and treatment of thromboembolic disorders.1 However, given the variability of response to standard dose among individuals and narrow therapeutic index, choosing a correct dose of warfarin is remained challenging. The variability of response to standard dose of warfarin depends on several.
  3. By mouth. For Neonate (initiated under specialist supervision). Initially 200 micrograms/kg for 1 dose on day 1, then reduced to 100 micrograms/kg once daily for the following 3 days, subsequent doses dependent on INR levels, induction dose may need to be altered according to condition (e.g. abnormal liver function tests, cardiac failure), concomitant interacting drugs, and if baseline INR.
  4. Coumadin (warfarin) dose: The usual dose of Coumadin (warfarin) is that which maintains your INR reading within therapeutic range which is INR 2.0 to INR 2.5. The dose to achie The dose to achie.
  5. .
  6. consider a booster dose of 1 ½ - 2 times daily maintenance dose consider resumption of prior maintenance dose if factor causing decreased INR is transient [eg: missed warfarin dose(s)] if a dosage adjustment is needed, increase maintenance dose by 5%-10

Coumadin/ warfarin pills come in different colors, and each color corresponds to a different dose (see graphic below). Difference Between Brand-Name and Generic Medications Generic drugs are supposed to have the same dosage, therapeutic effects, route of administration, side effects, and strength as the original drug • Your warfarin dose may change from time to time depending on your on INR • Keep a record of every INR result and warfarin dose that you have taken. Write down all warfarin doses and the date of the next INR test • Warfarin should be taken around the same time every day. It may be taken with food or on an empty stomach and may be taken. Warfarin treatment has a narrow therapeutic range, requiring meticulous monitoring and dosage titration. Individual dosage requirement has recently partly been explained by genetic variation of the warfarin metabolizing enzyme CYP2C9 and the Vitamin K-activating enzyme VKORC1. In the WARIS-II study, comparing three different antithrombotic regimens after myocardial infarction, warfarin. Warfarin is the most widely prescribed oral anticoagulant agent approved for the treatment and prevention of thromboembolic events [1]. However, due to the narrow therapeutic range and the large inter-individual variability of dose, establishment of optimal warfarin dose for anti-coagulation is difficult and the risk of adverse reactions is.

Use this form to record taking your daily Warfarin dosage. Includes a section to log your dosage if you are on a combination dose e.g. 3/4/4/3/4/4; Download and Print Off. Download and save for electronic use. Warfarin Treatment +INR Record Background and Purpose—Recent clinical trials have established that adjusted-dose warfarin (international normalized ratio [INR] 2.0 to 3.0) is highly effective in the reduction of ischemic stroke in patients with nonvalvular atrial fibrillation (AF).We hypothesized that the introduction of fixed low-dose warfarin alone or in combination with aspirin (300 mg) could normalize hemostatic. Although the same genes determine warfarin dose requirements in different ethnic groups, 29 the frequency of the individual gene variants differs, 29,30 and algorithms that are specific to ethnic. Genetic factors most correlated with warfarin dose requirements are variations in the genes encoding the enzymes cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKOR). Patients receiving warfarin who possess one or more genetic variations in CYP2C9 and VKORC1 are at increased risk of adverse drug events and require significant dose reductions to achieve a therapeutic. Warfarin is the most commonly used vitamin K antagonist.It has demonstrated effectiveness for the primary and secondary prevention of venous thromboembolism, for the prevention of systemic embolism in patients with prosthetic heart valves or atrial fibrillation, as an adjunct in the prophylaxis of systemic embolism after myocardial infarction, and for reducing the risk of recurrent myocardial.

Coumadin (warfarin sodium) dose, indications, adverse

Warfarin (Coumadin, Jantoven) is a prescription drug used to treat DVTs, reduction of pulmonary embolism and atrial fibrillation, and prevent strokes and heart attacks. Side effects include jaundice, hair loss, purple, painful toes, bloating, and more. Drug interactions, Dosing, and pregnancy and breastfeeding side effects are provided Posology. Adults and elderly patients: The typical induction dose of warfarin is 10 mg daily for 2 days, but this should be tailored to individual requirements.Baseline prothrombin measurements (PT) should be taken before beginning therapy with warfarin. The daily maintenance dose of warfarin is usually 3 to 9 mg taken at the same time each day

One dose of coumadin or warfarin is effective between 2 to 5 days, however daily dosage is important to for maintaining constant blood levels. Effects accumulate with repeated dosage due to the time taken for vitamin K-depending clotting factors to renew. INR ranges vary depending with what is being treated and specific guidelines Warfarin is a derivative of coumarin which interferes with the cyclic interconversion of vitamin K and its epoxide. Vitamin K is an important factor in the normal function of the coagulation system Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with nonvalvular atrial fibrillation Ann InternMed 2009;150:73-83. Gage B, Eby C, Johnson J, Deych E et al. Use of Pharmacogenetic and Clinical Factors to Predict the Therapeutic Dose of Warfarin The Warfarin dose required to achieve the target INR varies for each person. Any changes that are made to your Warfarin dose will be explained to you at the Warfarin Clinic/GP. If you do not understand your new dose please ask staff at the Warfarin Clinic/GP to explain it again. 6 Warfarin has been used for more than 60 years and is approved for multiple indications. 1 By monitoring the international normalized ratio (INR), the warfarin dose can be tailored to the individual patient. Increasing the time in therapeutic range (TTR) optimizes safety and effectiveness. 2 This article explores some pearls and pitfalls of warfarin use in relation to INR monitoring, which.

Warfarin Dose Adjustments, Anticoagulation Clinic UC San

  1. Medicines information from Great Ormond Street Hospital on warfarin
  2. K intake and cytochrome P450 IIC polypeptide9.
  3. K dose Check INR Comment < 5: withhold: Nil: within 1 to 2 days: Can recommence warfarin at a reduced dose in 24-48 hours when INR in therapeutic range: 5-9: withhold: Nil: within 24 hours. To check INR is not rising: Resume warfarin at a reduced dose when the INR in the therapeutic range. May need to withhold warfarin for.
  4. First, although there are known factors to consider when starting or adjusting warfarin dosages, such as age, sex, race, and drug interactions, pharmacogenetic testing adds another variable for clinicians to better estimate the initial warfarin dose and can assist clinicians in adjusting the dosage of warfarin even after several doses and INRs.
  5. Warfarin dose. Always take exactly the right dose. If you accidentally take too much warfarin, contact your doctor. Warfarin brands come in different strength tablets. Your doctor may give you a prescription for more than one tablet strength to make up the right dose. The tablets are colour coded to help identify different strengths

Warfarin: a blood-thinning medicine to treat and prevent

Adjust the warfarin dose to maintain a target INR of 2.5 (INR range, 2 to 3) for all treatment durations. The duration of treatment is based on the indication as follows: For patients with a DVT or PE secondary to a transient (reversible) risk factor, treatment with warfarin for 3 months is recommended Warfarin has a narrow therapeutic range and care is required with all concomitant therapy. The individual product information for any new concomitant therapy should be consulted for specific guidance on warfarin dose adjustment and therapeutic monitoring. If no information is provided the possibility of an interaction should be considered I have been on warfarin for 12 years so there have been numerous times that I have forgotten! I was advised by my Dr. that if I miss my 8:30 pm dose that I can take that dose anytime before 10:00 am the next day. This has work well for me with no problem The daily maintenance dose of warfarin differs greatly between individuals, commonly between 0.5 mg/day and 15 mg/day, and often fluctuates over time. The average maintenance dose is about 4.5 mg/day, although this is lower in the elderly Warfarin dose requirements are affected by many factors, such as gender, age, diet, race, concomitant medication and genetic factors. Pharmacogenomics, the study of the interaction of an individual's genotype and drug response, can help to optimize drug efficacy while minimizing adverse drug reactions 4, 5, 10

Warfarin is an anticoagulant. It is most likely to be the drug popularly referred to as a blood thinner, yet this is a misnomer, since it does not affect the thickness or viscosity of blood. Instead, it acts on the liver to decrease the quantity of a few key clotting factors in blood that allow. Genetic associations with weekly warfarin dose, adjusted for age, gender, BMI and smoking status are shown in Table 1 for European-Americans, African-Americans and combined adjusted for race. As expected, in European-Americans, six of the nine SNPs tested for association with stable warfarin dose were highly statistically significant at p. The dose of warfarin sodium (Coumadin ®, Jantoven ®) your healthcare provider recommends will vary, depending on how you respond to the medication (this is monitored using regular blood tests).As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so

Video: Warfarin: Low dose nomograms (Elderly patients) - GlobalRP

Warfarin is known to cross the placental barrier, which means that an unborn fetus will be exposed to the drug. Warfarin can cause the fetus to bleed, and it is also associated with spontaneous abortion, preterm birth, and stillbirth. Another syndrome, warfarin embryopathy, occurs when exposure to warfarin early in pregnancy causes birth defects Some foods can affect how warfarin works in your body and may affect your treatment and dose. Avoid sudden large increases or decreases in your intake of foods high in vitamin K (such as broccoli, cauliflower, cabbage, brussels sprouts, kale, spinach, and other green leafy vegetables, liver , green tea , certain vitamin supplements ) Paritaprevir (in fixed-dose combination) decreases the anticoagulant effect of warfarin. Manufacturer advises monitor INR and adjust dose. Severity of interaction

ESC 2012 Update of Atrial Fibrillation Guidelines - OralSubcutaneous Adjusted-Dose Unfractionated Heparin vs Fixed

Never take a double dose. Warfarin can make it easier for you to bleed. Seek emergency help if you have any bleeding that will not stop. You will need frequent INR or prothrombin time tests (to measure your blood-clotting time and determine your warfarin dose). You must remain under the care of a doctor while taking warfarin Taking warfarin. It's very important that you take warfarin exactly as directed. Don't increase your prescribed dose unless the doctor in charge of your care advises you to. Warfarin is taken once a day, usually in the evening. It's important to take your dose at the same time each day, before, during or after a meal RESULTS: The geometric mean dose of warfarin was 4.57 mg and 5% of patients were prescribed 10 mg or greater. There was a noticeable decrease in dose with increasing age, which averaged about 6 mg for patients aged 30 but 3.5 mg for those aged 80. Men required slightly more warfarin than women

Since warfarin usually is metabolized very the slowly, the exact daily dose is not as important as the average dose over a several day period. So, your clinician may consider having you take about the same amount of warfarin each week using different daily doses that are feasible with the larger, dye-free tablet The instructions with most drugs, including Warfarin say that you should never double up if you miss a dose, just carry on as normal. The absorption time of Warfarin is about 4 hours and the half life is 40 hours, so you would expect it to be MUCH less tolerant of an overdose than a missed dose RESULTS. The CYP4F2 rs2108622 CT/TT group took a significantly higher stable warfarin dose (3.2 mg day −1) than the CC group (2.9 mg day −1, 95% CI 0.2, 1.0, P= 0.033). The multiple linear regression model included VKORC1 3673G>A, CYP2C9, CYP4F2 genotypes and clinical characteristics. The model could explain 56.1% of the variance in stable warfarin dose in Han Chinese patients with MHVR The variability in warfarin dose explained by CYP2C9 genotype was 6.4% (average dose) and 7.9% (stable dose) among European Americans and 1% African American (Table 6). European American, but not African American patients with a variant CYP2C9 genotype required significantly lower warfarin dose compared to their wild-type genotype comparators The warfarin dosage also had to be doubled at the beginning of rifampicin therapy. However, four weeks after rifampicin discontinuation, an excessively high INR was observed (7.22), with three-day macroscopic hematuria and the need for an immediate reduction in the warfarin dosage. A therapeutic and stable INR was eventually attained at 50% of.

Coumadin (Warfarin (Oral)) - Side Effects, InteractionsRats and Mice Pest Control | Pesticide Research InstitutePPT - Review of Anticoagulants: Unfractionated heparin LowWhat are the P450 inhibitor and inducer drugs?SAVAYSA® (edoxaban) Dosing for Patients | HCP Site
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